MovDisordV3, Main, Exploration, bibRecord, 000769

Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia

Identifieur interne : 000769 ( Main/Exploration ); précédent : 000768; suivant : 000770

Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia

Auteurs : Morvarid Karimi [États-Unis] ; Stephen M. Moerlein [États-Unis] ; Tom O. Videen [États-Unis] ; Y. Su [États-Unis] ; Hubert P. Flores [États-Unis] ; Joel S. Perlmutter [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:4086787

English descriptors

KwdEn :
- Adult, Aged, Benzazepines (pharmacokinetics), Benzofurans (pharmacokinetics), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Dystonic Disorders (pathology), Dystonic Disorders (radionuclide imaging), Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Receptors, Dopamine D1 (metabolism).
MESH :
- chemical , metabolism : Receptors, Dopamine D1.
- chemical , pharmacokinetics : Benzazepines, Benzofurans.
- metabolism : Corpus Striatum.
- pathology : Dystonic Disorders.
- radionuclide imaging : Corpus Striatum, Dystonic Disorders.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography.

Abstract

Background

Multiple studies demonstrate decreases in striatal D2-like (D2, D3) radioligand binding in primary focal dystonias. Although most investigations have focused on D2 specific receptors (D2R), a recent study suggests that the decreased D2-like binding may be due to a D3 specific (D3R) abnormality. However, only limited data exist on the role of D1 specific receptors (D1R) and the D1R-mediated pathways within basal ganglia in dystonia. Metabolic PET data in primary generalized dystonia suggest resting state overactivity in the D1R-mediated "direct" pathway leading to excessive disinhibition of motor cortical areas. This work investigated whether striatal D1-like receptors are affected in primary focal dystonias.

Methods

We measured striatal (caudate and putamen) specific binding of the D1-like radioligand [¹¹C] NNC 112 using PET in 19 patients with primary focal dystonia (cranial, cervical or arm) and 18 controls.

Results

We did not detect a statistically significant difference in striatal D1-like binding between the two groups. This study had 91% power to detect a 20% difference, making a false negative study unlikely.

Conclusions

Since [¹¹C] NNC112 has a high affinity for D1-like receptors, very low affinity for D2-like receptors and minimal sensitivity to endogenous dopamine levels, we conclude that D1-like receptor binding is not impaired in these primary focal dystonias.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086787

DOI: 10.1002/mds.25720
PubMed: 24151192
PubMed Central: 4086787

Affiliations:

Le document en format XML

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<term>Aged</term>
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<term>Benzofurans (pharmacokinetics)</term>
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<term>Dystonic Disorders (radionuclide imaging)</term>
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<term>Humans</term>
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<term>Benzofurans</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Multiple studies demonstrate decreases in striatal D2-like (D2, D3) radioligand binding in primary focal dystonias. Although most investigations have focused on D2 specific receptors (D2R), a recent study suggests that the decreased D2-like binding may be due to a D3 specific (D3R) abnormality. However, only limited data exist on the role of D1 specific receptors (D1R) and the D1R-mediated pathways within basal ganglia in dystonia. Metabolic PET data in primary generalized dystonia suggest resting state overactivity in the D1R-mediated "direct" pathway leading to excessive disinhibition of motor cortical areas. This work investigated whether striatal D1-like receptors are affected in primary focal dystonias.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We measured striatal (caudate and putamen) specific binding of the D1-like radioligand [<sup>11</sup>
C] NNC 112 using PET in 19 patients with primary focal dystonia (cranial, cervical or arm) and 18 controls.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">We did not detect a statistically significant difference in striatal D1-like binding between the two groups. This study had 91% power to detect a 20% difference, making a false negative study unlikely.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Since [<sup>11</sup>
C] NNC112 has a high affinity for D1-like receptors, very low affinity for D2-like receptors and minimal sensitivity to endogenous dopamine levels, we conclude that D1-like receptor binding is not impaired in these primary focal dystonias.</p>
</sec>
</div>
</front>
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{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4086787
   |texte=   Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia
}}

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Movement Disorders (revue)

Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia

Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia

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Abstract

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	Movement Disorders (revue)
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